Anesthetic spindles serve as EEG markers of the depth variations in anesthesia induced by multifarious general anesthetics in mouse experiments.

ABSTRACT:

Background

Mice play a crucial role in studying the mechanisms of general anesthesia. However, identifying reliable EEG markers for different depths of anesthesia induced by multifarious agents remains a significant challenge. Spindle activity, typically observed during NREM sleep, reflects synchronized thalamocortical activity and is characterized by a frequency range of 7-15 Hz and a duration of 0.5-3 s. Similar patterns, referred to as "anesthetic spindles," are also observed in the EEG during general anesthesia. However, the variability of anesthetic spindles across different anesthetic agents and depths is not yet fully understood.

Method

Mice were anesthetized with dexmedetomidine, propofol, ketamine, etomidate, isoflurane, or sevoflurane, and cortical EEG recordings w

SUBMITTER: You Y 

PROVIDER: S-EPMC11671261 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature