Association between changes in thyroid hormones and incident type 2 diabetes using joint models of longitudinal and time-to-event data: more than a decade follow up in the Tehran thyroid study.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) poses a significant public health challenge, contributing to considerable morbidity and mortality worldwide, which necessitates urgent preventive measures. Thyroid disorders, prevalent in many individuals, are intricately linked to metabolic health, yet studies on their relationship with T2DM yield inconsistent results-some suggesting an increased risk with abnormal thyroid hormone levels, while others indicate potential protective effects. This study investigated the association between changes in serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels and the incidence of type 2 diabetes mellitus.

Methods

Data from 1938 individuals aged ≥20 in the Tehran Thyroid Study cohort were used, spanning four examination cyc

SUBMITTER: Amirabadizadeh A 

PROVIDER: S-EPMC11671262 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature