Clinical presentations, electrophysiologic features, and long-term follow-up in Lambert-Eaton myasthenic syndrome: a series of six patients.

ABSTRACT:

Background

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of the presynaptic neuromuscular junction associated with antibody mediated dysfunction of voltage-gated calcium channels (VGCCs). LEMS can exist as a paraneoplastic syndrome, paraneoplastic-LEMS (P-LEMS), when associated with tumors, most commonly, small cell lung carcinoma (SCLC) or as a non-paraneoplastic condition (NP-LEMS) when no malignancies are detected.

Methods

A retrospective chart review was conducted in 3 tertiary hospitals in Saudi Arabia for patients diagnosed with LEMS between January 2010 and January 2020. Patients meeting all the following criteria were included: (1) weakness or fatigability of one or more extremity or oculo-bulbar muscles, (2) 60% or higher increment of compound m

SUBMITTER: Alhammad RM 

PROVIDER: S-EPMC11671300 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature