The burden of chronic pain in transgender and gender diverse populations: Evidence from a large US clinical database.

ABSTRACT:

Background

Chronic pain, affecting approximately 20% of the global population, is the leading cause of disability worldwide. Transgender individuals are disproportionately exposed to chronic pain risk factors compared with the cisgender population. This study compares the incidence of chronic pain between transgender and cisgender individuals and examines the impact of gender affirming hormone therapy, anxiety, and depression on chronic pain.

Methods

The study analysed medical records data of 56,470 transgender men and 41,882 transgender women in the TrinetX database. Six cohorts were created: transgender women either receiving oestrogen or no intervention, transgender men receiving testosterone or no intervention and cohorts of cisgender males and females. Unmatched age-adj

SUBMITTER: Tabernacki T 

PROVIDER: S-EPMC11671315 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature