S100A proteins show a spatial distribution of inflammation associated with the glioblastoma microenvironment architecture.

ABSTRACT: Background: Glioblastoma IDH wild type (GBM IDH wt) has a poor prognosis and a strongly associated with inflammatory processes. Inflammatory molecules generate positive feedback with tumor cells fueling tumor growth as well as recruitment of immune cells that promote aggressiveness. Although the role of many inflammatory molecules is well known, there are many macromolecules, such as the S100A proteins, whose role is only now beginning to be established. Methods: Using RNA-seq, bioinformatics tools and a cohort of glioma patients to validate the results, we have analysed the inflammatory processes involved in glioma. Transcriptional profiles were also used to define biological processes of relevance to specific S100A proteins. Finally, we characterized the relevant immune pop

SUBMITTER: Comitre-Mariano B 

PROVIDER: S-EPMC11671380 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature