<i>STIL</i> enhances the development of lung adenocarcinoma by regulating the glycolysis pathway.

ABSTRACT:

Background

To investigate SCL/TAL 1 interrupting locus (STIL)'s role and prognostic significance in lung adenocarcinoma (LUAD) progression, we examined STIL and E2 promoter binding factor 1 (E2F1) expression and their impacts on LUAD prognosis using Gene Expression Profiling Interactive Analysis (GEPIA).

Methods

Functional assays including CCK-8, wound-healing, 5-ethynyl-2-deoxyuridine (EdU), Transwell assays, and flow cytometry, elucidated STIL and E2F1's effects on cell viability, proliferation, apoptosis, and migration. Gene set enrichment analysis (GSEA) identified potential pathways, while metabolic assays assessed glucose metabolism.

Results

Our findings reveal that STIL and E2F1 are overexpressed in LUAD, correlating with adverse out

SUBMITTER: Wang L 

PROVIDER: S-EPMC11671407 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature