The causal association between asthma and the risk of frailty: A two-sample Mendelian randomization study.

ABSTRACT:

Background

The correlation between asthma and frailty is increasingly garnering attention. The association between asthma and frailty remains inconclusive in observational studies, and the causality of this relationship still needs to be established.

Aims

Therefore, we employed two-sample Mendelian randomization analyses using genetic instruments to determine the causal association of asthma on frailty.

Methods

Two-sample Mendelian randomization (MR) analyses were performed to assess the causal effect of asthma on frailty. The genetic variants strongly associated with asthma (P < 5E-08) during the discovery and replication stages were derived from a recent meta-analysis of genome-wide association studies (GWAS) (N = 408,442) in the UK Biobank and a GWAS in the FinnGen

SUBMITTER: Ning P 

PROVIDER: S-EPMC11671423 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature