Systemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study.

ABSTRACT:

Introduction

We investigated the relationship between systematic regulators of inflammation and the risk of age-related macular degeneration (AMD), both wet and dry forms, by using bidirectional, two-sample Mendelian randomization (MR).

Methods

We performed bidirectional two-sample Mendelian randomization analysis using genome-wide study (GWAS) data for 91 plasma proteins from 14,824 individuals of European descent across 11 study groups. Next, we utilized data from the FinnGen consortium to study AMD using the inverse- variance-weighted approach for Mendelian randomization. Additional analyses involved MR-Egger, Weighted median, Weighted mode, MR-PRESSO, and MR- Steiger filtering techniques.

Results

We identified 16 cytokines associated AMD outcomes and post FDR corr

SUBMITTER: Liu X 

PROVIDER: S-EPMC11671502 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature