Critical review of aging clocks and factors that may influence the pace of aging.

ABSTRACT:

Background and objectives

Aging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative review, we aim to discuss the currently available aging clocks, ranging from epigenetic aging clocks to visual skin aging clocks.

Methods

We performed a literature search on PubMed/MEDLINE databases with keywords including: "aging clock," "aging," "biological age," "chronological age," "epigenetic," "proteomic," "microbiome," "telomere," "metabolic," "inflammation," "glycomic," "lifestyle," "nutrition," "diet," "exercise," "psychosocial," and "technology."

Results

Notably, several CpG regions, plasma proteins, inflam

SUBMITTER: Min M 

PROVIDER: S-EPMC11671503 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature