MAFG-DT promotes prostate cancer bone metastasis through activation of the Wnt/β-catenin pathway.

ABSTRACT:

Background

Prostate cancer (PCa) ranks as the second leading cause of cancer-related mortality among men. Long non-coding RNAs (lncRNAs) are known to play a regulatory role in the development of various human cancers. LncRNA MAFG-divergent transcript (MAFG-DT) was reported to play a crucial role in tumor progression of multiple human cancers, such as pancreatic cancer, colorectal cancer, bladder cancer, and gastric cancer. Nevertheless, the specific function of MAFG-DT in the context of bone metastasis in PCa remains inadequately understood.

Methods

The expression level of MAFG-DT was analyzed in published datasets and further confirmed in clinical samples and cell lines by RT-qPCR and in situ hybridization assays. Additionally, we further examined the effect of MAFG-

SUBMITTER: Wang C 

PROVIDER: S-EPMC11671513 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature