A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response.

ABSTRACT: Fatty acids are known to have significant effects on the properties of cancer cells. Therefore, these compounds have been incorporated into therapeutic strategies. However, few studies have examined the effects of individual fatty acids and their interactions in depth. This study analyzed the effects of various fatty acids on cancer cells and revealed that stearic acid, an abundant saturated fatty acid, had a stronger inhibitory effect on cell growth than did palmitic acid, which is also an abundant saturated fatty acid, by inducing DNA damage and apoptosis through the unfolded protein response (UPR) pathway. Intriguingly, the negative effects of stearate were reduced by the presence of oleate, a different type of abundant fatty acid. We combined a stearate-rich diet with the inhibition of

SUBMITTER: Ogura J 

PROVIDER: S-EPMC11671534 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature