Role of the Forkhead box family protein FOXF2 in the progression of solid tumor: systematic review.

ABSTRACT:

Background

FOXF2 was reported to involve in a variety of biological behaviors that include the development of the central nervous system, tissue homeostasis, epithelia-mesenchymal interactions, regulation of embryonic development, and organogenesis.

Purpose

Understanding how FOXF2 influences the growth and development of cancer could provide valuable insights for researchers to develop novel therapeutic strategies.

Results

In this review, we investigate the underlying impact of FOXF2 on tumor cells, including the transformation of cellular phenotype, capacity for migration, invasion, and proliferation, colonization of circulating cells, and formation of metastatic nodules. In addition, we discuss the molecular mechanisms of FOXF2 in different cancers, including hepato

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11671575 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature