Essential role of Card11 in airway hyperresponsiveness in high-fat diet-induced obese mice.

ABSTRACT: A high-fat diet (HFD) can induce airway hyperresponsiveness (AHR) in obese mice, independent of allergic sensitization. This study aimed to identify the key molecules related to AHR in HFD-induced obese mice. In a cluster analysis of time series gene expression in the adipose and lung tissues of HFD-induced obese mice, we identified the Caspase Recruitment Domain Family Member 11 (Card11) gene as an essential molecule. We measured CARD11 expression in peripheral blood mononuclear cells (PBMCs) from obese individuals with asthma and performed Card11 signal inhibition in HFD-induced obese mice via Card11 siRNA. Card11 expression was significantly increased in M1 macrophages (IL-1β⁺CD11c⁺CD206^- in CD11b⁺) in adipose tissue and in ILC3s (RORγt^+<

SUBMITTER: Lee HS 

PROVIDER: S-EPMC11671588 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature