Distribution and impact of p16^INK4A+ senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction.

ABSTRACT: Cellular senescence, recognized as a key hallmark of aging, leads to the accumulation of senescent cells in various tissues over time. While the detrimental effects of these cells on age-related pathological conditions are well-documented, there is still limited information about how senescent cells are distributed in normal tissues of both young and aged organs. Our research indicates that fully senescent p16^INK4A+ cells are rarely identified in the parenchyma of organic tissues and in the stromal cells crucial for structural maintenance, such as fibroblasts and smooth muscle cells. Instead, p16^INK4A+ cells are more commonly found in immune cells, whether they reside in the organ or are infiltrating. Notably, p16^INK4A+ senescent T cells have been observed

SUBMITTER: Park SS 

PROVIDER: S-EPMC11671602 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature