HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation.

ABSTRACT:

Background

Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized.

Methods

We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental validation studies focused on l

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11671622 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature