Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.

ABSTRACT: Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore harms body homeostasis. Elucidating the protective mechanisms whereby the organism copes with sustained or repetitive blood pressure rises is therefore a topical challenge. Here we address this issue in the adrenal medulla, the master neuroendocrine tissue involved in the secretion of catecholamines, influential hormones in blood pressure regulation. Combining electrophysiological techniques with catecholamine secretion assays on acute adrenal slices from spontaneously hypertensive rats, we show that chromaffin cell stimulus-secretion coupling is remodeled, resulting in a less efficient secretory function primarily upon sustained cholinergic challenges. The remodeling is supported by revamped both

SUBMITTER: Paille V 

PROVIDER: S-EPMC11671677 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature