Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum.

ABSTRACT: The cerebellum is a highly conserved brain compartment of vertebrates. Genetic diseases of the human cerebellum often lead to degeneration of the principal neuron, the Purkinje cell, resulting in locomotive deficits and socio-emotional impairments. Due to its relatively simple but highly conserved neuroanatomy and circuitry, these human diseases can be modeled well in vertebrates amenable for genetic manipulation. In the recent years, cerebellar research in zebrafish has contributed to understanding cerebellum development and function, since zebrafish larvae are not only molecularly tractable, but also accessible for high resolution in vivo imaging due to the transparency of the larvae and the ease of access to the zebrafish cerebellar cortex for microscopy approaches. Therefore, zebrafish

SUBMITTER: Namikawa K 

PROVIDER: S-EPMC11671678 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature