Development and validation of a novel immune-related prognostic model and the potential metastatic mechanism in synovial sarcoma.

ABSTRACT:

Background

Several clinical trials have shown that immunotherapy plays a pivotal role in the treatment of patients with metastatic synovial sarcoma. Immune-related genes (IRGs) have been demonstrated to predict the immunotherapy response in certain malignant tumours. However, the clinical significance of IRGs in patients with synovial sarcoma (SS) is still unclear.

Methods

We first combined the immune-related ImmPort gene set to search for SS related to metastatic and differentially expressed immune-related genes (DEIRGs) in the GSE40021 dataset from the GEO database. The soft tissue sarcoma database in TCGA was used for univariate Cox regression analyses to identify DEIRGs that were related to overall survival and to build an immune-related prognostic assessment model.

R

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11671775 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature