Efficacy and safety of therapies for Still's disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Still's disease.

ABSTRACT:

Objectives

To analyse the efficacy and safety of treatments for Still's disease and macrophage activation syndrome (MAS).

Methods

Medline, Embase and Cochrane Library were searched for clinical trials (randomised, randomised controlled trial (RCT), controlled and clinical controlled trial (CCT)), observational studies (retrospective, longitudinal observational retrospective (LOR), prospective and longitudinal observational prospective (LOP)) and systematic reviews (SRs), in which the populations studied were patients with Still's disease and MAS. The intervention was any pharmacological treatment (approved or under evaluation) versus any comparator drug or placebo, and as outcomes, any relevant efficacy and safety event. The risk of bias (RoB) was assessed with the Cochrane

SUBMITTER: Bindoli S 

PROVIDER: S-EPMC11671904 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature