Effects of resveratrol on aortic growth in patients with Marfan syndrome: a single-arm open-label multicentre trial.

ABSTRACT:

Background

Resveratrol, a dietary supplement that intervenes in cellular metabolism, has been shown to reduce aortic growth rate in a mouse model of Marfan syndrome (MFS), a condition associated in humans with life-threatening aortic complications, often preceded by aortic dilatation. The primary objective of this study was to investigate the effects of resveratrol on aortic growth rate in patients with MFS .

Methods

In this investigator-initiated, single-arm open-label multicentre trial, we analysed resveratrol treatment in adults aged 18-50 years with MFS. The primary endpoint was the change in estimated annual aortic growth at five predefined levels in the thoracic aorta after 1 year of resveratrol treatment, evaluated using a linear mixed model. Aortic diameters were mea

SUBMITTER: van Andel MM 

PROVIDER: S-EPMC11671954 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature