Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis.

ABSTRACT:

Background

The association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although several observational studies assessing this relationship have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomisation (MR) the effect of CCT on POAG risk and whether this effect is mediated by intraocular pressure (IOP) changes.

Methods

We used 24 single-nucleotide polymorphisms (SNPs) associated with CCT (p value<5×10^-8) from a genome-wide association study (GWAS) (N=17 803) provided by the International Glaucoma Genetics Consortium and 53 SNPs associated with IOP (p value<5×10^-8) from a GWAS of

SUBMITTER: Katsimpris A 

PROVIDER: S-EPMC11672028 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature