Activin A promoted the anti-tumor effect of ActRIIA ^high CD8⁺ T cells in mouse hepatoma.

ABSTRACT:

Background

Activin A, a noteworthy member of the TGF-β superfamily. Activin A can regulate the biological functions of various immune cells, such as macrophages, neutrophils, NK cells, etc. The purpose of this study is to investigate the regulatory effect and related mechanisms of activin A on CD8⁺ T cells.

Methods

This study established a mouse subcutaneous transplantation model of hepatoma to explore whether activin A has a regulatory effect of CD8⁺ T cells. And reveal the biological characteristics of ActRIIA high CD8⁺ T cells.

Results

We discovered that CD8⁺ T cells express ActRIIA, ActRIIB, and Smad2,3,4. Unlike high-dose activin A, low-dose activin A increased the content of CD8⁺ T cells while also suppressi

SUBMITTER: Hu L 

PROVIDER: S-EPMC11672029 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature