Impact of NICE clinical guidelines for prevention and treatment of neonatal infections on antibiotic use in very preterm infants in England and Wales: an interrupted time series analysis.

ABSTRACT:

Objective

To assess the impact of publication of UK National Institute for Health and Care Excellence (NICE) guidelines on the prevention and treatment of early-onset infections (EOIs) in neonates (clinical guideline 149 (CG149), published in 2012, and its 2021 update (NG195) on antibiotic use in very preterm infants.

Design

Interrupted time series analysis using data from the National Neonatal Research Database.

Setting

Neonatal units in England and Wales.

Participants

Infants born at 22-31 weeks' gestation from 1 January 2010 to 31 December 2022 and survived to discharge.

Interventions

Publication of CG149 (August 2012) and NG195 (April 2021).

Main outcome measures

Measures of antibiotic use, aggregated by month of birth: antibiotic use rate (AU

SUBMITTER: Saunders M 

PROVIDER: S-EPMC11672067 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature