Systematic review: differences in complete blood count component rhythms.

ABSTRACT:

Study objectives

The complete blood count (CBC) is one of the most commonly ordered blood tests with a large range of reference values that does not consider time of day for interpretation. Our objective was to systematically review this topic to report on peak and trough timing of CBC values.

Methods

A systematic search was performed for studies evaluating any component of the CBC with at least three collections over 24 hours. The studies were screened based on the predetermined eligibility criteria. Meta-analysis of aggregated data was analyzed with polynomial functions and forest plots.

Results

In total, 164 full-text articles were screened and 32 included in the final analysis with 548 total patients considering either leukocytes (n = 13), erythrocytes (

SUBMITTER: Busza A 

PROVIDER: S-EPMC11672111 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature