Discordant Information on Blinding in Trial Registries and Published Research: A Systematic Review.

ABSTRACT:

Importance

Blinding of individuals involved in randomized clinical trials (RCTs) can be used to protect against performance and biases, but discrepancies in the reporting of methodological features between registered protocols and subsequent trial publications may lead to inconsistencies, thereby reintroducing bias.

Objective

To investigate inconsistency in blinding as reported in trial registries and publications.

Data sources

An exploratory dataset and a validation dataset were created. The exploratory dataset consisted of RCTs included in systematic reviews of adverse events from the SMART Safety database published between January 1, 2015, to January 1, 2020. The validation dataset was based on a literature search on PubMed for all registered RCTs published within

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11672156 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature