Brownian Motion Paving the Way for Molecular Translocation in Nanopores.

ABSTRACT: Tracing fast nanopore-translocating analytes requires a high-frequency measurement system that warrants a temporal resolution better than 1 µs. This constraint may practically shift the challenge from increasing the sampling bandwidth to dealing with the rapidly growing noise with frequencies typically above 10 kHz, potentially making it still uncertain if all translocation events are unambiguously captured. Here, a numerical simulation model is presented as an alternative to discern translocation events with different experimental settings including pore dimension, bias voltage, the charge state of the analyte, salt concentration, and electrolyte viscosity. The model allows for simultaneous analysis of forces exerting on a large analyte cohort along their individual trajectories; these fo

SUBMITTER: Lee WY 

PROVIDER: S-EPMC11672184 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature