The specific medications for pulmonary arterial hypertension at functional class III to IV: a systematic review and meta-analysis.

ABSTRACT:

Purpose

To systematically evaluate the clinical efficacy and safety of targeted drugs in patients with pulmonary arterial hypertension (PAH) with cardiac function grades III-IV, and conduct a meta-analysis.

Methods

Two researchers independently searched the PubMed, EMBASE, and Cochrane Library databases for relevant studies, with the search period extending from the establishment of the databases to March 2024. Meta-analysis was performed using statistical software Review Manager 5.4. Heterogeneity among studies was analyzed using either a random-effects model or a fixed-effects model. When the I2 value was < 50%, indicating good homogeneity, the fixed-effects model was adopted; otherwise, the random-effects model was used. For continuous variables, the 6-minute walk distanc

SUBMITTER: Li Q 

PROVIDER: S-EPMC11672201 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature