Association between migraine and mitochondria: A Mendelian randomization study.

ABSTRACT:

Background and objective

Mitochondria are important organelles functioning in metabolic processes, inflammatory response and neurological disorders. Migraines are chronic and paroxysmal neurological disorders characterized by recurrent episodes of severe headache and other neurological symptoms. We explored whether mitochondria may be genetically and/or causally associated with migraine.

Methods

Summary-level statistics of mitochondrial DNA copy number (mtDNA-CN), 69 mitochondria related exposures and migraine with aura, migraine without aura, migraine with aura and triptan purchases, migraine with aura, drug-induced, migraine without aura and triptan purchases and migraine without aura, drug-induced, were collected from genome-wide association studies (GWAS). The analysis e

SUBMITTER: Hong MY 

PROVIDER: S-EPMC11672378 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature