Proton Tunneling Allows a Proton-Coupled Electron Transfer Process in the Cancer Cell.

ABSTRACT: Proton-coupled electron transfer (PCET) is a fundamental redox process and has clear advantages in selectively activating challenging C-H bonds in many biological processes. Intrigued by this activation process, we aimed to develop a facile PCET process in cancer cells by modulating proton tunneling. This approach should lead to the design of an alternative photodynamic therapy (PDT) that depletes the mitochondrial electron transport chain (ETC), the key redox regulator in cancer cells under hypoxia. To observe this depletion process in the cancer cell, we monitored the oxidative-stress-induced depolarization of mitochondrial inner membrane potential (MMP) using fluorescence lifetime imaging microscopy (FLIM). Typically, increasing metabolic stress of cancer cells is reflected in a nontriv

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11672552 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature