50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations.

ABSTRACT:

Background

The complementarity-determining region (CDR) of antibodies represents the most diverse region both in terms of sequence and structural characteristics, playing the most critical role in antibody recognition and binding for immune responses. Over the past decades, several numbering schemes have been introduced to define CDRs based on sequence. However, the existence of diverse numbering schemes has led to potential confusion, and a comprehensive evaluation of these schemes is lacking.

Methods

We employ statistical analyses to quantify the diversity of CDRs compared to the framework regions.

Results

Comparative analyses across different numbering schemes demonstrate notable variations in CDR definitions. The Kabat and AbM numbering schemes tend to incorporate

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC11672675 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature