Some Human Anti-Glycan Antibodies Lack the Ability to Activate the Complement System.

ABSTRACT: Background. Naturally occurring human antibodies against glycans recognize and quickly eliminate infectious bacteria, viruses and aberrantly glycosylated neoplastic malignant cells, and they often initiate processes that involve the complement system. Methods. Using a printed glycan array (PGA) containing 605 glycoligands (oligo- and polysaccharides, glycopeptides), we examined which of the glycan-binding antibodies are able to activate the complement system. Using this PGA, the specificities of antibodies of the IgM and IgG classes were determined in the blood serum of healthy donors (suggested as mostly natural), and, then, using the same array, it was determined which types of the bound immunoglobulins were also showing C3 deposition. Results. It was found that abou

SUBMITTER: Shilova N 

PROVIDER: S-EPMC11672820 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature