Selective Ni(I)/Ni(III) Process for Consecutive Geminal C(sp³)-C(sp²) Bond Formation.

ABSTRACT: Ni-catalyzed multicomponent cross-couplings have emerged as a powerful strategy for efficiently constructing complex molecular architectures from a diverse array of organic halides. Despite its potential, selectively forming multiple chemical bonds in a single operation, particularly in the realm of cross-electrophile coupling catalysis, remains a significant challenge. In this study, we have developed a consecutive open-shell reductive Ni catalysis, enabling the formation of two geminal C(sp³)-C(sp²) bonds from two stereoelectronically similar C(sp²)-I reactants in conjunction with a methylene electrophile. Using zirconaaziridine and elemental Mg⁰ as reductants, this protocol exhibits broad applicability across a wide range of (hetero)aromatic,

SUBMITTER: Li X 

PROVIDER: S-EPMC11673112 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature