CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis.

ABSTRACT: Central nervous system (CNS) resident memory CD8 T cells (T_RM) that express IFN-γ contribute to neurodegenerative processes, including synapse loss, leading to memory impairment. Here, we show that CCR2 signaling in CD8 T_RM that persist within the hippocampus after recovery from CNS infection with West Nile virus (WNV) significantly prevents the development of memory impairments. Using CCR2-deficient mice, we determined that CCR2 expression is not essential for CNS T cell recruitment or virologic control during acute WNV infection. However, transcriptomic analyses of forebrain CCR2⁺ versus CCR2^- CD8 T_RM during WNV recovery reveal that CCR2 signaling significantly regulates hippocampal CD8 T_RM phenotype and function via extri

SUBMITTER: Ai S 

PROVIDER: S-EPMC11673327 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature