N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) and multiple system atrophy (MSA) are classified as α-synucleinopathies and are primarily differentiated by their clinical phenotypes. Delineating these diseases based on their specific α-synuclein (α-Syn) proteoform pathologies is crucial for accurate antemortem biomarker diagnosis. Newly identified α-Syn pathologies in PD raise questions about whether MSA exhibits a similar diversity. This prompted the need for a comparative study focusing on α-Syn epitope-specific immunoreactivities in both diseases, which could clarify the extent of pathological overlap and diversity, and guide more accurate biomarker development.

Methods

We utilised a multiplex immunohistochemical approach to detect multiple structural domains of α-Syn proteoforms acr

SUBMITTER: Wiseman JA 

PROVIDER: S-EPMC11673343 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature