Tranexamic acid in hip and spine surgery for children with cerebral palsy - a PRISMA-compliant scoping review.

ABSTRACT: Many children with cerebral palsy (CP) are frail and require major hip and/or spine surgeries associated with substantial blood loss. Tranexamic acid (TXA) is commonly used to reduce blood loss, but there is uncertainty around the optimal dose and timing of administration. There have been reviews in sub-populations and specific dosing regimens, but a broad overview of the available literature is lacking. The aim of this review was to map available evidence on TXA in hip and spine surgery for children with CP. Given the heterogeneous literature, a prospectively registered scoping review was conducted. Eligibility criteria were broad. Three screeners were involved, with the senior author consulted when disagreements were not resolved through discussion.Titles and abstracts of 14,609 records

SUBMITTER: Gould D 

PROVIDER: S-EPMC11673357 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature