CD57⁺ EMRA CD8⁺ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.

ABSTRACT:

Background

Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8⁺ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 2018 and March 2021.

Results

Flow cytometry and unsupervised analysis were employed to characterize Effector Memory CD45RA⁺ (EMRA) and CD8⁺ T cell senescence at bas

SUBMITTER: Gonnin C 

PROVIDER: S-EPMC11673364 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature