First Characterization of a Cyanobacterial Xi-Class Glutathione S-Transferase in Synechocystis PCC 6803.

ABSTRACT: Glutathione S-transferases (GSTs) are evolutionarily conserved enzymes crucial for cell detoxication. They are viewed as having evolved in cyanobacteria, the ancient photosynthetic prokaryotes that colonize our planet and play a crucial role for its biosphere. Xi-class GSTs, characterized by their specific glutathionyl-hydroquinone reductase activity, have been observed in prokaryotes, fungi and plants, but have not yet been studied in cyanobacteria. In this study, we have analyzed the presumptive Xi-class GST, designated as Slr0605, of the unicellular model cyanobacterium Synechocystis PCC 6803. We report that Slr0605 is a homodimeric protein that has genuine glutathionyl-hydroquinone reductase activity. Though Slr0605 is not essential for cell growth under standard photoautotrophi

SUBMITTER: Marceau F 

PROVIDER: S-EPMC11673678 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature