Alterations of the paired maternal vaginal microbiome and neonatal meconium microbiome in vulvovaginal candidiasis positive pregnant women.

ABSTRACT:

Background

Women with vulvovaginal candidiasis (VVC) are known to experience vaginal microbial dysbiosis. However, the dynamic alterations of the vaginal microbiome in pregnant women with VVC and its effect on neonatal gut microbiome remain unclear. This study aims to characterize the vaginal microbiome in pregnant women with VVC and its impact on their offspring's meconium microbiome.

Methods

Forty-four pregnant women, including 17 with VVC (VVC group) and 27 healthy controls (HC group), along with their 44 offspring, were enrolled in this study. Maternal vaginal samples were collected during the pre- and post-delivery phases. Meconium samples from their newborns were also obtained. Microbial communities were characterized using 16S rRNA sequencing.

Results

The vagin

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11673766 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature