YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression.

ABSTRACT:

Background

Neuroblastoma (NB), the most prevalent solid tumor in children, arises from sympathetic nervous system and accounts for 15% of pediatric cancer mortality. This malignancy exhibits substantial genetic and clinical heterogeneity, thus complicating treatment strategies. Poly(ADP-ribose) polymerase 1 (PARP1), a key enzyme catalyzing polyADP-ribosylation (PARylation), plays critical roles in various cellular processes, and contributes to tumorigenesis and aggressiveness. However, the functions and regulatory mechanisms of PARP1 in NB progression still remain to be determined.

Methods

The association of PARP1 expression with NB patients' survival was analyzed by mining of R2 database. Western blotting, reverse transcription-polymerase chain reaction, MTT colorimetric, s

SUBMITTER: Yang C 

PROVIDER: S-EPMC11673900 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature