Rupture mechanics of blood clot fibrin fibers: A coarse-grained model study.

ABSTRACT: Thrombosis, when occurring undesirably, disrupts normal blood flow and poses significant medical challenges. As the skeleton of blood clots, fibrin fibers play a vital role in the formation and fragmentation of blood clots. Thus, studying the deformation and fracture characteristics of fibrin fiber networks is the key factor to solve a series of health problems caused by thrombosis. This study employs a coarse-grained model of fibrin fibers to investigate the rupture dynamics of fibrin fiber networks. We propose a new method for generating biomimetic fibrin fiber networks to simulate their spatial geometry in blood clots. We examine the mechanical characteristics and rupture behaviors of fibrin fiber networks under various conditions, including fiber junction density, fiber tortuosity, fib

SUBMITTER: Gu B 

PROVIDER: S-EPMC11674026 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature