The Cellular and Transcriptomic Early Innate Immune Response to BCG Vaccination in Mice.

ABSTRACT: It is established that BCG vaccination results in the development of both a specific immune response to mycobacterial infections and a nonspecific (heterologous) immune response, designated as trained immunity (TRIM), to other pathogens. We hypothesized that local BCG immunization may induce an early immune response in bone marrow and spleen innate immunity cells. The early transcriptomic response of various populations of innate immune cells, including monocytes, neutrophils, and natural killer (NK) cells, to BCG vaccination was examined. To this end, C57Bl/6J mice were subcutaneously immunized with 10⁶ CFU of BCG. Three days following BCG administration, the three cell populations were collected from the control and BCG-vaccinated groups using FACS. All cell populations obtain

SUBMITTER: Kondratyeva LG 

PROVIDER: S-EPMC11674076 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature