Structural-functional connectivity decoupling in multiscale brain networks in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a progressive neurodegenerative disease associated with functional and structural alterations beyond the nigrostriatal dopamine projection. However, the structural-functional (SC-FC) coupling changes in combination with subcortical regions at the network level are rarely investigated in PD.

Methods

SC-FC coupling networks were systematically constructed using the structural connectivity obtained by diffusion tensor imaging and the functional connectivity obtained by resting-state functional magnetic resonance imaging in 53 PD and 72 age- and sex-matched healthy controls (HCs). Then, we explored how SC-FC coupling varied within and between several well-defined functional domains.

Results

Results showed that the SC-FC coupling in p

SUBMITTER: Zou T 

PROVIDER: S-EPMC11674082 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature