Hazard assessment of nanomaterials: how to meet the requirements for (next generation) risk assessment.

ABSTRACT:

Background

Hazard and risk assessment of nanomaterials (NMs) face challenges due to, among others, the numerous existing nanoforms, discordant data and conflicting results found in the literature, and specific challenges in the application of strategies such as grouping and read-across, emphasizing the need for New Approach Methodologies (NAMs) to support Next Generation Risk Assessment (NGRA). Here these challenges are addressed in a study that couples physico-chemical characterization with in vitro investigations and in silico similarity analyses for nine nanoforms, having different chemical composition, sizes, aggregation states and shapes. For cytotoxicity assessment, three methods (Alamar Blue, Colony Forming Efficiency, and Electric Cell-Substrate Impedance Sensing) are appli

SUBMITTER: Longhin EM 

PROVIDER: S-EPMC11674189 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature