Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women.

ABSTRACT:

Objective

Referring all women who tested positive for human papillomavirus (HPV) 16/18 to colposcopy may lead to potential over-referral issues. Triage tests based on cytology results face challenges in achieving accurate diagnoses. Our study aims to assess the clinical effectiveness of PAX1/JAM3 methylation (CISCER) test as a triage method for HPV 16/18-positive women.

Methods

From November 2021 to December 2022, a total of 334 women who tested positive for HPV 16/18 and were referred to colposcopy at The Second Affiliated Hospital of Zhejiang University School of Medicine were studied. The clinical utility of the CISCER test, cytology, and the combination of CISCER with cytology as potential triage tests was compared.

Results

We observed a significant increase in th

SUBMITTER: Fei J 

PROVIDER: S-EPMC11674251 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature