Flexible Electrochemical Biosensor Using Nanostructure-Modified Polymer Electrode for Detection of Viral Nucleic Acids.

ABSTRACT: In the biosensor field, the accurate detection of contagious disease has become one of the most important research topics in the post-pandemic period. However, conventional contagious viral biosensors normally require chemical modifications to introduce the probe molecules to nucleic acids such as a redox indicator, fluorescent dye, or quencher for biosensing. To avoid this complex chemical modification, in this research, mismatched DNA with an intercalated metal ion complex (MIMIC) is employed as the probe sequence. In addition, the MIMIC is fabricated on a lithography-assisted nanostructure-modified flexible polymer electrode. On this flexible electrode, as a proof-of-concept study, a human papillomavirus (HPV-16 and -18) was detected by the MIMIC with a high accuracy. The developed bios

SUBMITTER: Han J 

PROVIDER: S-EPMC11674301 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature