Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease.

ABSTRACT: Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer's disease (AD). Computational simulations and animal experiments have hinted at the theory of activity-dependent degeneration as the cause of this hub vulnerability. However, two critical issues remain unresolved. First, past research has not clearly distinguished between two scenarios: hub regions facing a higher risk of connectivity disruption (targeted attack) and all regions having an equal risk (random attack). Second, human studies offering support for activity-dependent explanations remain scarce. We refined the hub disruption index to demonstrate a hub disruption pattern in functional connect

SUBMITTER: Tu JC 

PROVIDER: S-EPMC11674321 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature