Beyond hemoglobin: Critical role of 2,3-bisphosphoglycerate mutase in kidney function and injury.

ABSTRACT:

Aim

2,3-bisphosphoglycerate mutase (BPGM) is traditionally recognized for its role in modulating oxygen affinity to hemoglobin in erythrocytes. Recent transcriptomic analyses, however, have indicated a significant upregulation of BPGM in acutely injured murine and human kidneys, suggesting a potential renal function for this enzyme. Here we aim to explore the physiological role of BPGM in the kidney.

Methods

A tubular-specific, doxycycline-inducible Bpgm-knockout mouse model was generated. Histological, immunofluorescence, and proteomic analyses were conducted to examine the localization of BPGM expression and the impact of its knockout on kidney structure and function. In vitro studies were performed to investigate the metabolic consequences of Bpgm knockdown under osmotic

SUBMITTER: Kulow VA 

PROVIDER: S-EPMC11674375 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature