Integrated proteomics and metabolomics network analysis across different delivery modes in human pregnancy: a pilot study.

ABSTRACT:

Background

Delivery mode has been linked to child health, e.g., allergic disease. However, it remains unclear whether protein and metabolite differences across different delivery modes may underlie child development.

Methods

A cohort comprising 16 spontaneous onset vaginal delivery (VD), 16 prelabor cesarean delivery on maternal request (CS), and 8 intrapartum cesarean section (Intra_CS) women were analyzed using label-free proteomic and untargeted metabolomics assays on amniotic fluid and cord blood samples, respectively. We used weighted gene co-expression network analyses (WGCNA) to identify modules of highly correlated proteins or metabolites that associated with delivery modes and related clinical traits. KEGG enrichment analyses were performed to investigate the biolog

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11674393 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature