Disseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is a highly aggressive disease characterized by early metastasis. Aneuploid CD31^- disseminated tumor cells (DTCs) and CD31⁺ disseminated tumor endothelial cells (DTECs) residing in the bone marrow are generally considered as the initiators of metastatic process. However, the clinical significance of DTCs and DTECs in SCLC remains poorly understood. The aim of this study is to investigate the clinical implications of diverse subtypes of highly heterogeneous DTCs and DTECs in SCLC patients.

Methods

Subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH) was applied to enrich and perform comprehensive morphologic, karyotypic, and phenotypic characterization of aneuploid DTCs and DTECs

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11674436 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature