A two-sample Mendelian randomization study reveals the causal effects of statin medication on gut microbiota abundance in the European population.

ABSTRACT:

Background

Observational studies have reported changes in gut microbiota abundance caused by long-term statin medication therapy. However, the causal relation between statin medication and gut microbiota subsets based on genetic variants remains unclear.

Methods

We used genome-wide association study (GWAS) data on statin medication from the FinnGen database and gut microbiota abundance GWAS data from the IEU OpenGWAS project. A Mendelian randomization (MR) analysis was conducted to evaluate the causal effect of statin medication on gut microbiota abundance using the inverse variance weighting (IVW) method, MR-Egger regression, and weighted median approach. Meanwhile, heterogeneity and pleiotropy analyses were also undertaken in this study.

Results

Statin medication wa

SUBMITTER: Zhou P 

PROVIDER: S-EPMC11674602 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature